Wednesday, October 28, 2009

Collective Aspirin Problems

Having just taken an 14-months-expired aspirin, I felt that I should check to see whether taking expired aspirin is safe. (Note to self: do this in the opposite order from now on.) Fortunately, it seems that it is -- there was a big study on this:
The military was sitting on a $1 billion stockpile of drugs and facing the daunting process of destroying and replacing its supply every 2 to 3 years, so it began a testing program to see if it could extend the life of its inventory. The testing, conducted by the US Food and Drug Administration (FDA), ultimately covered more than 100 drugs, prescription and over-the-counter. The results showed that about 90% of them were safe and effective as far as 15 years past their original expiration date.
As the author of the article says, this is one of those things where medicine manufacturers don't have any incentive to tell us that their drugs are good for a longer period of time. If I don't have any aspirin and I'm hung over, I'm going to buy some regardless of what expiration date is printed on the package. Short expirations don't keep me from buying the product. But if I have some expired aspirin, I might throw it away one afternoon and plan to buy a new bottle. Knowing this, manufacturers are going to err on the side of short expiration dates.

So who does the studies to figure out the truth about this? Well, the military, since they have a $1 billion drug stockpile that they don't want to throw away. You have to be really big -- like, Army big -- before funding a study like this is in your own interest. Otherwise, it's a classic collective action problem. All us consumers would be happy to pay a dime each for a big study on the issue, but there's no way for us to coordinate our action, especially as free riders could find ways to get the information without paying in. There's probably tons more information like this out there that could save us money or improve our health, but which we don't know because no one entity finds it in their interest to pay for the relevant study. Until then, drugmakers and medical device manufacturers will continue to take our money with marketing gimmicks (they spend far more on marketing than R&D) and give us poor value.

This will continue until there's some Army-like health care provider large enough that it's worth its while to pay for expensive but comprehensive and rigorous studies. And that's why we love Comparative Effectiveness Research, and look forward to the day when medical innovation is saved by a big government health care plan.

[Update: Medscape is behind a paywall. For some reason I can get to the article through Google, but not via the link above. Minus the approving comments from a UChicago psychopharmacologist, the link to the expired medicine article is here.]

11 comments:

Brock said...

Damn. I just threw away a half-bottle of expired (by about 6 months) aspirin.

chris said...

Medscape is behind a registration-wall, but its not a pay-wall.

its one of the better medicine related websites, though.

Unknown said...

The problem with old aspirin is that it starts breaking down to vinegar. Acetylsalicylic acid --> acetic acid.

But the "expiration date" imprinted by a manufacturer is much more about sales than pharmacology.

Griffin Brooks said...

nizonide 500mg is utilized for the treatment of loose bowels in patients with protozoal diseases brought about by the protozoa Giardia and Cryptosporidium. Use this medicine after consulting a doctor. Buy Online from Most trusted online Medicine Store in the USA.

anna joy said...

Cenforce 200 is that the complete package delivered by warrior Laboratories in Asian countries. These pills contain anti-impotence drugs of a 200mg area unit utilised for erectile brokenness (ineptitude). this is often viewed collectively of the foremost outstanding treatment selections accessible for the blokes once they take care of problems in their sexual organs. In the USA, the medication is sold beneath the brand of anti-impotence drug tablets. it's a doctor supported drug; it implies the medication is often taken simply once counselled by a specialist.
Read more:
Vidalista 20 mg
Nizagara 100

Royball said...

Malegra 100 Sildenafil, advanced around the world, treats male Dysfunction issues or Impotence issues. This pill sildenafil tablet works by limiting phosphodiesterase type 5 in the body. It hence stops the degradation of cGMP (Cyclic Guanosine Monophosphate). Availability of cGMP relaxes the veins in the penile area and appropriately helps erection when there is a necessity for sexual action.
Malegra 200 || Aurogra 100

Pills4ever said...

A medication that has a place with the gathering of focal sensory system depressants or prescriptions that make you sluggish. Zopisign 10 is utilized to treat sleep deprivation (inconvenience nodding off) and lessens daytime uneasiness in individuals experiencing an absence of rest. It permits you to nod off quicker and stay unconscious longer, assisting you with awakening feeling refreshed and revived.
Zopifresh 7.5 || Zopisign 7.5

Cenforce Pills said...

The essential utilization of Cenforce Professional is to treat weakness in men. Sexual feebleness, otherwise called Erectile Dysfunction, is a condition where a man can't get and keep an erection to perform sexual action. Sildenafil Citrate, the salt in Cenforce Professional, likewise treats Pulmonary Arterial Hypertension ( a sort of hypertension).

Alternative ED Treatment Medicine is Here
Vilitra 60 | silditop 100 | snovitra 20

Cenforce Pills said...

Buy Cenforce D in chipset price Online – Cenforcepills
What is Cenforce D?
[url=https://www.cenforcepills.com/product/cenforce-d/]Cenforce D[/url] is a medication that helps treat male weakness. It works by expanding the bloodstream to the penile region of the body. This helps men in getting and keeping an erection.
Utilization of Cenforce D pills
This medication treats erectile brokenness (ineptitude). Erectile brokenness is a sexual problem in guys who can't accomplish a sufficiently hard erection for sex.
Capacity
Get this medication far from dampness, heat, and direct light in a shut holder at room temperature.
Keep out of youngsters' span. Try not to store terminated meds.
Incidental effects
Even though Cenforce D is protected to utilize, it makes specific side impacts, very much like some other drug. Normal aftereffects might include:
Cerebral pain or unsteadiness
• Flushing (warmth, redness, or shivery inclination)
• Unusual vision
• Acid reflux, queasiness, or annoyed stomach
• Rest issues (sleep deprivation)
• Muscle torment or back torment
• Runny or stodgy nose

What are Alvitra 40mg Tablets
[url=https://www.cenforcepills.com/product/alvitra-40-mg/]alvitra 40[/url] is a prescription endorsed for the treatment of erectile brokenness in men. This medication is a creation of conventional Vardenafil which is its chief fixing known for improving the power in men to carry on with a blissful sexual life. The class of phosphodiesterase type 5 inhibitors incorporates Vardenafil which fills in as a protein inhibitor advancing erection among men. This medication is accessible in strong structures, i.e., tablets, and is the most secure as well as a supportive prescription to determine the issue of erectile brokenness. It works for practically every one of the men by the imprint of its quick activity and life span.

IS SILDAMAX SAFE?
[url=https://www.cenforcepills.com/product/sildamax-100-mg/]Sildamax[/url] is a drug that is normally used to treat erectile brokenness or comparable weakness issues. It is made in India and cases contain a similar dynamic fixing as Viagra to be specific, Sildenafil Citrate, nonetheless, the item (which ordinarily arrives in a 100mg tablet) has not finished quality standard assessments for the lawful deal in the UK.

Cenforce Pills said...

Buy Cenforce D in chipset price Online – Cenforcepills
What is Cenforce D?
Cenforce D is a medication that helps treat male weakness. It works by expanding the bloodstream to the penile region of the body. This helps men in getting and keeping an erection.
Utilization of Cenforce D pills
This medication treats erectile brokenness (ineptitude). Erectile brokenness is a sexual problem in guys who can't accomplish a sufficiently hard erection for sex.
Capacity
Get this medication far from dampness, heat, and direct light in a shut holder at room temperature.
Keep out of youngsters' span. Try not to store terminated meds.
Incidental effects
Even though Cenforce D is protected to utilize, it makes specific side impacts, very much like some other drug. Normal aftereffects might include:
Cerebral pain or unsteadiness
• Flushing (warmth, redness, or shivery inclination)
• Unusual vision
• Acid reflux, queasiness, or annoyed stomach
• Rest issues (sleep deprivation)
• Muscle torment or back torment
• Runny or stodgy nose

What are Alvitra 40mg Tablets
alvitra 40 is a prescription endorsed for the treatment of erectile brokenness in men. This medication is a creation of conventional Vardenafil which is its chief fixing known for improving the power in men to carry on with a blissful sexual life. The class of phosphodiesterase type 5 inhibitors incorporates Vardenafil which fills in as a protein inhibitor advancing erection among men. This medication is accessible in strong structures, i.e., tablets, and is the most secure as well as a supportive prescription to determine the issue of erectile brokenness. It works for practically every one of the men by the imprint of its quick activity and life span.

IS SILDAMAX SAFE?
Sildamax is a drug that is normally used to treat erectile brokenness or comparable weakness issues. It is made in India and cases contain a similar dynamic fixing as Viagra to be specific, Sildenafil Citrate, nonetheless, the item (which ordinarily arrives in a 100mg tablet) has not finished quality standard assessments for the lawful deal in the UK.

vidalista 40 said...

Take Vidalista tablets whole, with a drink of water - Genericmedsaustralia Vidalista 20mg Tablet contains tadalafil, the active ingredient in most ED medications. It is produced by Centurion Laboratories Pvt. Ltd., a CGMP-compliant pharmaceutical company based in Gujarat, India. The tablet comes in a variety of strengths, with the 60 mg version recommended for severe cases of erectile dysfunction. For mild to moderate cases of erectile dysfunction, a 10mg tablet can be used. More, Alternative Tablets Below: Kamagra Jelly Australia | Buy cialis austrelia | Vidalista 60mg